Macrotricyclic host molecules with basket shaped cavities |
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Authors: | Bernhard Dung Fritz Vögtle |
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Affiliation: | (1) Institut für Organische chemie und Biochemie der Universität Bonn, Gerhard-Domagk-Strasse 1, D-5300 Bonn 1, Germany |
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Abstract: | The syntheses of several macrotricyclic hexalactams (1–3) and of a corresponding hexalactone (4) are described in detail for the first time. The molecules have a basket shaped skeleton and contain a non-collapsible cavity, the size and shape of which is varied by use of spacer groups. Compounds1–3 selectively form crystalline adducts with ethanol as guest; the macrotricyclic hexaester4 does not. Evidence for an interaction of1 with ethanol was obtained by exchange experiments with perdeuteroethanol. Complexation experiments in solution did not show significant host/guest interactions with the guest chosen. |
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Keywords: | Cavity complex formation ethanol adduct ethanol inclusion host/guest chemistry inclusion compounds lactam lactone macrotricyclic compounds perdeuteroethanol spacer groups |
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