A microfluidic device based on droplet storage for screening solubility diagrams |
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Authors: | Laval Philippe Lisai Nicolas Salmon Jean-Baptiste Joanicot Mathieu |
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Affiliation: | LOF, unité mixte Rhodia-CNRS-Bordeaux 1, 178 avenue du Docteur Schweitzer, F-33608 Pessac cedex, France. philippe.laval-exterieur@eu.rhodia.com |
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Abstract: | This work describes a new microfluidic device developed for the rapid screening of solubility diagrams. In several parallel channels, hundreds of nanolitre volume droplets of a given solution are first stored with a gradual variation in the solute concentration. Then, the application of a temperature gradient along these channels enables us to read directly and quantitatively phase diagrams, concentration vs. temperature. We show, using a solution of adipic acid, that we can measure ten points of the solubility curve in less than 1 hr and with only 250 microL of solution. |
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