Stereoselective synthesis of 2-epi-jaspine B via base-catalyzed intramolecular oxy-Michael conjugate addition approach |
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| Authors: | Gowrisankar Reddipalli Mallam Venkataiah Mithilesh Kumar Mishra Nitin W. Fadnavis |
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| Affiliation: | aBiotransformations Laboratory, Organic Division-I, Indian Institute of Chemical Technology, Habsiguda, Hyderabad 500 007, India |
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| Abstract: | 2-epi-Jaspine B has been synthesized starting from (−)-diethyl tartrate in 12 simple steps and 26.6% overall yield. The key intermediate was obtained via stereoselective base-catalyzed intramolecular oxy-Michael conjugate addition followed by tandem hydrogenation/hydrogenolysis. |
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