| 5,10,15,20-中位-四(4-氨基苯基)卟吩合成方法的改进 |
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| 引用本文： | 李和平,郭灿城.5,10,15,20-中位-四(4-氨基苯基)卟吩合成方法的改进[J].有机化学,2000,20(5):830-832. |
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| 作者姓名： | 李和平 郭灿城 |
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| 作者单位： | 湖南大学化学化工学院,长沙,410082 |
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| 摘 要： | 在还原剂维生素C存在下，将4-氨基苯甲醛与吡咯在丙酸中缩合得到5,10,15,20-中位-四(4-氨基苯基)卟吩，操作简单，产率高于文献方法。
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| 关 键 词： | 缩合反应 卟吩P 苯甲醛P 维生素C |
| 修稿时间： | 2000年1月6日 |
An improved synthetic method for preparing 5,10,15,20-meso-tetra(4- aminophenyl)porphine |
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| LI He-Ping,GUO Can-Cheng.An improved synthetic method for preparing 5,10,15,20-meso-tetra(4- aminophenyl)porphine[J].Chinese Journal of Organic Chemistry,2000,20(5):830-832. |
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| Authors: | LI He-Ping GUO Can-Cheng |
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| Abstract: | An improved Adler method for preparing 5, 10, 15, 20 - meso - tetra(4 - aminophenyl) porphine ( TAPPH2 ) is presented. TAPPH2 was synthesized by direct condensation of pyrrole with 4 - aminobenzaldehyde in reflux-ing propanoic acid in the presence of vitamin C. This new synthetic strategy for preparing TAPPH2 should greatly expand synthetic entries to porphines containing atnino groups. As a complementary to the Adler procedure this methodology allows forpreparation of aminophenylporphines from sensitive aminobenzaldehydes in ca 20% yields without suffering from difficult purification problems. |
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| Keywords: | 4 - aminobenzaldehyde 5 10 15 20 - meso - tetra (4 - aminophenyl)porphine synthesis |
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