Synthesis,Spectral Characterization and Antioxidant Activity of Novel Zafirlukast Sulfonyl Derivatives |
| |
Authors: | Donka Rajasekhar Doddaga Srinivasulu Chenchugari Sridhar Godlaveti Vijay Narasimha Kumar Peddakonda Ramesh |
| |
Affiliation: | 1. Department of Chemistry, Sri Venkateswara University, Tirupati‐517?502, A.P., India, Tel: +91‐9493816701;2. Department of Chemistry, University of the Free State, Post Box 339, Bloemfontein 9300, South Africa;3. Department of Pharmacy, Sri Padmavathi School of Pharmacy, Tiruchanoor‐517?501, A.P., India |
| |
Abstract: | A new series of cyclopentyl 3‐(2‐methoxy‐4‐(piperazine‐1‐carbonyl)benzyl)‐1‐methyl‐1H‐indol‐5‐ylcarbamate sulfonyl derivatives were synthesized by the reaclion of 4‐((5‐(cyclopentyloxycarbonylamino)‐1‐methyl‐1H‐indol‐3‐yl)methyl)‐3‐methoxybenzoic acid (ZAK drug intermediate) with Boc piperazine in the presence of EDC?HCl, HOBt, TEA in DMF followed by deboxylation by using 2N HCl or 35 % HCl in acetone to get an intermediate compound. Further, this compound was treated with various substituted benzene sulfonyl chlorides in the presence of TEA in THF to afford title compounds. All the title compounds were characterized by 1HNMR, 13CNMR, IR and mass spectral data. The title compounds and starting material were evaluated for their antioxidant activity by using the DPPH, H2O2 and NO methods. The results revealed that some of the compounds have shown significant antioxidant activity. |
| |
Keywords: | Zafirlukast Boc piperazine Sulfonyl derivatives Antioxidant activity |
|
|