A Facile and Efficient Synthesis of 4‐Arylidene‐2‐phenyl‐5(4H)‐oxazolones and Their Antimicrobial Evaluation against Selected Human and Phytopathogens |
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| Authors: | Christopher Voosala Padma Suhasini Kilaru Uday Kumar Dasari |
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| Affiliation: | 1. Department of Organic Chemistry, Andhra University, Visakhapatnam, Andhra Pradesh, India;2. Department of Chemistry in BS&H, Vignan Institute of Engineering for Women, Visakhapatnam, Andhra Pradesh, India;3. Department of Human Genetics, Andhra University, Visakhapatnam, Andhra Pradesh, India |
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| Abstract: | A simple and convenient method has been developed for the synthesis of a series of 2‐(4‐substituted phenyl)‐4‐(substituted arylidene)‐1,3‐oxazol‐5‐ones ( 5a–j ) via reactions of hippuric acid with differently substituted aromatic aldehydes ( 4a–j ) in sodium acetate, potassium acetate, calcium acetate, and ammonium acetate, respectively, which were tested for their efficiency as catalysts in both conventional and microwave‐assisted synthetic methods in presence of 4 Å zeolites. The title compounds were evaluated for their antimicrobial properties against selected human pathogens (bacterial and fungal) and phytopathogens (fungal) and were compared with standard drugs. The results of the study are reported. |
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| Keywords: | 5(4H)‐Oxazolones Hippuric acid Phytopathogens Microwave synthesis Calcium acetate |
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