PEG-grafted chitosan as an injectable thermoreversible hydrogel |
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Authors: | Bhattarai Narayan Matsen Frederick A Zhang Miqin |
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Institution: | Department of Materials Science & Engineering, University of Washington, Seattle, WA 98195-2120, USA. |
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Abstract: | PEG-grafted chitosan was formulated such that its solution undergoes a thermally reversed phase transition from an injectable free-flowing solution at low temperature to a gel at body temperature. Aqueous solutions of PEG-grafted chitosan can be prepared at physiological pH values, thereby allowing safe incorporation of bioactive molecules. This injectable thermoreversible hydrogel is potentially suitable for a wide range of biomedical applications, particularly in sustained in vivo drug release and tissue engineering. An aqueous solution of PEG-grafted chitosan polymer is injectable at low temperatures but forms a gel at body temperature. |
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Keywords: | biocompatibility chitosan hydrogels poly(ethylene glycol) viscosity |
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