Asymmetric Addition of Diethylzinc to Aldehydes Catalyzed by Chiral γ_Amino Alcohols |
| |
作者姓名: | Qian Yong XU Tong Xing WU Xin Fu PAN* Department of Chemistry National Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 |
| |
作者单位: | Qian Yong XU,Tong Xing WU,Xin Fu PAN* Department of Chemistry,National Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou 730000 |
| |
基金项目: | Hong Kong Polytechnic University for the financial support. |
| |
摘 要: | Although the asymmetric additions of diethylzinc to aldehydes have been extensively studied in the presence of chiral catalyst, most of the chiral ligands tested are b-amino alcohols1. In this report, the synthesis of chiral gamino alcohols 1-4 from the reaction of (+)-camphor and (-)-menthone with 2-lithiomethyl-6-methyl-pyridine or 2-picolly- lithium2, which give a single diasteromer as determined by 1H NMR with high yields (Scheme 1)3, and their application in the enantioselective additio…
|
本文献已被 CNKI 等数据库收录! |