用于内窥光学相干层析成像探头的小型化及焦深拓展技术

小型化探头是内窥光学相干层析成像(Optical coherence tomography,OCT)中的普遍需求。介绍了包括基于球透镜、光纤透镜、自聚焦光纤、自由曲面透镜、无透镜的OCT技术的发展历程,总结和比较了各种技术的优劣,为探头的小型化设计提出了建议。研究探头的焦深拓展技术对分辨人体内细胞的在体成像的发展具有重要意义。介绍了几种重要的适用于小型化探头的焦深拓展技术,其中基于模式干涉的探头由于易于制作、结构紧凑、传输效率高,同时具有可以优化工作距离、焦深和轴向光强均匀性的优点,在拓展小型化探头的焦深方面具有一定的发展潜力。

Probes for Endoscopic Optical Coherence Tomography:Minimized Design and Depth of Focus Extension

Minimized probe is a common requirement in endoscopic optical coherence tomography(OCT).We introduce the development of mainstream designs based on ball lens,fiber lens,graded index fiber,free form lens and free-lens,summarize their advantages and disadvantages,and put forward some suggestions for miniaturization of the probe.The development of probe with extended depth of focus(DOF)poses significance on imaging subcellular structure of human internal organs.We review several important techniques of DOF extension suitable for miniature probes,among which the probe based on mode interference is believed to have great potential because of its easy fabrication,compact structure,high light transmission efficiency,optimized working distance and DOF,and uniformity of axial light intensity.