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Synthesis and biological evaluation of novel 2,4,5-triaryl-1 H-pyrazol-3(2H)-ones as inhibitors of ALK5 |
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| Authors: | Xing Zhou Li Xian Ping Dai Kang Ying Lai Li Li Wang Zhi Bing Zheng Song Li |
| Abstract: | A series of 2,4,5-triaryl substituted 1H-pyrazol-3(2H)-ones,as ALK5 inhibitors,were desigened,synthesized and evaluated in vitro.Most compounds exhibited noticeable ALK5 inhibition activities at 1 μmol/L and displayed no significant cytotoxicities at 30 μmol/L. |
| Keywords: | Activin-like kinases5 (ALK5) Kinase inhibitors 1H-Pyrazol-3(2H)-ones novel biological evaluation Synthesis significant compounds inhibition activities synthesized in vitro inhibitors substituted series |
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