S(N)Ar-based, facile synthesis of a library of benzothiaoxazepine-1,1'-dioxides |
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| Authors: | Rolfe Alan Samarakoon Thiwanka B Klimberg Sarra V Brzozowski Marek Neuenswander Benjamin Lushington Gerald H Hanson Paul R |
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| Institution: | Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045-7582, USA. |
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| Abstract: | The construction of a library of benzothiaoxazepine-1,1'-dioxides utilizing a one-pot, S(N)Ar diversification-ODCT(50) scavenging protocol is reported. This protocol combines microwave irradiation to facilitate the reaction, in conjunction with a soluble ROMP-derived scavenger (ODCT) to afford the desired products in good overall purity. Utilizing this protocol, a 78-member library was successfully synthesized and submitted for biological evaluation. |
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