| Kinetics of the Inactivation of Creatine Kinase During Inhibition by Planar Anions |
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| 引用本文： | 张艳,陈培榕,邹晓明,王希成,周海梦. Kinetics of the Inactivation of Creatine Kinase During Inhibition by Planar Anions[J]. 中国科学B辑(英文版), 1993, 0(11) |
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| 作者姓名： | 张艳 陈培榕 邹晓明 王希成 周海梦 |
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| 作者单位： | Department of Chemistry，Tsinghua University，Beijing 100084，PRC，Department of Chemistry，Tsinghua University，Beijing 100084，PRC，Department of Biological Science and Biotechnology，Tsinghua University，Beijing 100084，PRC，State Key Laboratory of Biomacromolecules，Institute of Biophysics，Academia Sinica，Beijing 100101，PRC，Department of Biological Science and Biotechnology，Tsinghua University，Beijing 100084，PRC，State Key Laboratory of Biomacromolecules，Institute of Biophysics，Academia Sinica，Beijing 100101，PRC，Department of Biological Science and Biotechnology，Tsinghua University，Beijing 100084，PRC，State Key Laboratory of Biomacromolecules，Institute of Biophysics，Academia Sinica，Beijing 100101，PRC |
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| 摘 要： | The kinetic theory of the substrate reaction during the modification of enzyme activity previously described by Tsou has been applied to a study on the kinetics of slow irreversible inhibition of creatine kinase by planar anions. Kinetic equation of substrate reaction was derived according to the theoretical analysis and experiment data, and then was simplified. From the simplified equation for the substrate reaction in the presence of the inhibitors, the microscopic rate constants for the reaction of the inhibitors with enzyme were obtained. The mechanism of inhibition of enzyme activity was discussed.
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Kinetics of the Inactivation of Creatine Kinase During Inhibition by Planar Anions |
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| ZHANG Yan CHEN Pei-Rong. Kinetics of the Inactivation of Creatine Kinase During Inhibition by Planar Anions[J]. Science in China(Chemistry), 1993, 0(11) |
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| Authors: | ZHANG Yan CHEN Pei-Rong |
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| Abstract: | The kinetic theory of the substrate reaction during the modification of enzyme activity previously described by Tsou has been applied to a study on the kinetics of slow irreversible inhibition of creatine kinase by planar anions. Kinetic equation of substrate reaction was derived according to the theoretical analysis and experiment data, and then was simplified. From the simplified equation for the substrate reaction in the presence of the inhibitors, the microscopic rate constants for the reaction of the inhibitors with enzyme were obtained. The mechanism of inhibition of enzyme activity was discussed. |
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| Keywords: | creatine kinase inhibition activity kinetics. |
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