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Stereoselective synthesis of beta-substituted beta-amino sulfones and sulfonamides via addition of sulfonyl anions to chiral N-sulfinyl imines |
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| Authors: | Velázquez Francisco Arasappan Ashok Chen Kevin Sannigrahi Mousumi Venkatraman Srikanth McPhail Andrew T Chan Tze-Ming Shih Neng-Yang Njoroge F George |
| Affiliation: | Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033-1300, USA. francisco.velazquez@spcorp.com |
| Abstract: | [reaction: see text] A highly stereoselective synthesis of beta-amino sulfones and sulfonamides via addition of sulfonyl anions to chiral N-sulfinyl imines is described. The addition reaction proceeds in good yield (75-99%) and stereoselectivity. |
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