| 2-羰基丙酸(吡啶-4-甲酰基)腙稀土双核配合物的合成、表征及抗肿瘤活性 |
| |
| 引用本文： | 杨正银,王流芳,吴集贵,李兴玉.2-羰基丙酸(吡啶-4-甲酰基)腙稀土双核配合物的合成、表征及抗肿瘤活性[J].应用化学,1992,0(3):31-36. |
| |
| 作者姓名： | 杨正银 王流芳 吴集贵 李兴玉 |
| |
| 作者单位： | 兰州医学院, 兰州 730000 |
| |
| 摘 要： | 从2-羰基丙酸(吡啶-4-甲酰基)腙(H2PPFH)合成了13种组成为RE2(PPFH)3·nH2O(RE=La-Yb,n=2～3)的稀土腙固体配合物。通过红外、紫外、元素分析,电导及核磁共振谱等方法对其进行了表征。经药理实验发现配合物Eu2(PPFH)3·3H2O具有抗肿瘤活性。
|
| 关 键 词： | 腙 稀土配合物 抗肿瘤活性 合成 |
| 收稿时间： | 1991-03-09 |
| 修稿时间： | 1991-08-20 |
SYNTHESIS,CHARACTERIZATION AND ANTITUMOR ACTIVITY OF COMPLEXES OF 2-CARBONYLPROPIONYL (PYRIDINE-4-FORMYL) HYDRAZONE WITH RARE EARTHS |
| |
| Yang Zhengyin,Wang Liufang,Wu Jigui,Li Xingyu.SYNTHESIS,CHARACTERIZATION AND ANTITUMOR ACTIVITY OF COMPLEXES OF 2-CARBONYLPROPIONYL (PYRIDINE-4-FORMYL) HYDRAZONE WITH RARE EARTHS[J].Chinese Journal of Applied Chemistry,1992,0(3):31-36. |
| |
| Authors: | Yang Zhengyin Wang Liufang Wu Jigui Li Xingyu |
| |
| Institution: | Department of Chemistry, Lanzhou University, Lanzhou 73000 |
| |
| Abstract: | 2-Carbonylpropionyl (pyridine-4-formyl) hydrazone (H2PPPH)has been synthesized by a simple method. It is a weak acid, and the complexation was carried out in the water solution of rare earth carbonates. 13 complexes have general composition of RE2(PPFH)3·nH2O (RE=La～Yb, n=2～3). The structures and properties of the complexes were characterized by elemental analysis, IR, UV spectra, TGA-DTA, molar conductance and 1H NMR measuramcnts. Eu2(PPFH)3·3H2O was showed to have a certain antitumor activity. |
| |
| Keywords: | 2-carbonylpropionic acid isonicotinyl hydrazine hydrazone rare earth complex antitumor activity synthesis |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《应用化学》浏览原始摘要信息 |
| 点击此处可从《应用化学》下载免费的PDF全文 |
|
