| 吲哚并喹嗪衍生物的立体选择性合成 |
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| 引用本文： | 彭师奇,董颖,WINTERFELDT,E.吲哚并喹嗪衍生物的立体选择性合成[J].有机化学,1993,13(3):305-306. |
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| 作者姓名： | 彭师奇 董颖 WINTERFELDT E |
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| 作者单位： | 北京医科大学;Hannover大学有机化学研究所 |
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| 摘 要： | 用锂铝氢四还原卟啉得到卟啉醇,它与甲乙酮反应得相应的羟甲基氨基酮,在相转移条件下,它能被转化成光学纯吲哚并喹嗪衍生物.列出了环化机理的反应流程.
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| 关 键 词： | 环化 立体选择性 吲哚并喹嗪 卟啉 氢化锂铝 相转移 |
The stereoselective synthesis of indoloquinolizines |
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| Abstract: | Carboline I (R = CO2Me, R1 = H) was reduced by LiAlH4 to I (R = CH2OH, R1 = H) which was treated with MeCOCH:CH2 to give I (R = CH2OH, R1 = CH2CH2COMe). The latter compound was cyclized on treatment with AcCl under phase-transfer conditions to give the indoloquinolizine II. Intermediates in the cyclization were isolated and suggest the mechanism of the reaction. |
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| Keywords: | CYCLIZATION STEREOSELECTIVITY INDOLOQUINOLIZINE PORPHYRIN LITHIUM ALUMINIUM HYDRIDE |
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