Berkeleydione and berkeleytrione, new bioactive metabolites from an acid mine organism |
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Authors: | Stierle Donald B Stierle Andrea A Hobbs J David Stokken Janalee Clardy Jon |
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Affiliation: | Department of Chemistry, Montana Tech of the University of Montana, Butte, Montana 59701, USA. dstierle@mtech.edu |
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Abstract: | [structure: see text] Two novel hybrid polyketide-terpenoid metabolites were isolated from a Penicillium sp. growing in the Berkeley Pit Lake of Butte, Montana. Their structures were deduced by spectroscopic analysis and confirmed by single-crystal X-ray analysis on berkeleydione (1). Both compounds inhibited matrix metalloproteinase-3 and caspase-1, and berkeleydione showed activity toward non-small-cell lung cancer in NCI's human cell line antitumor screen. |
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