Total synthesis of the proposed structure for spirofungin B: a reassignment of the stereochemistry |
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Authors: | Zanatta Shannon D White Jonathan M Rizzacasa Mark A |
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Institution: | School of Chemistry, The University of Melbourne, Victoria 3010, Australia. |
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Abstract: | structure: see text] The total synthesis of the proposed structure for spirofungin B (2) is described. The data for the synthetic material did not compare with that for the natural product leading to the conclusion that the structure 2 assigned for spirofungin B is incorrect. Analysis of the NMR data reported for spirofungins A and B as well as related spiroketals allowed for the reassignment of the stereochemistry of spirofungin B to be that corresponding to 15-epi-spirofungin A (27). |
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