Chiral metallacyclophanes: self-assembly, characterization, and application in asymmetric catalysis |
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Authors: | Hua Jiang Lin Wenbin |
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Affiliation: | Department of Chemistry, CB 3290, University of North Carolina, Chapel Hill, North Carolina 27599, USA. |
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Abstract: | [structure: see text] A family of chiral metallacyclophanes has been readily assembled based on robust Pt-acetylide linkage and characterized by a variety of spectroscopic techniques and X-ray crystallography. The steric congestion around the chiral dihydroxy groups in rigid metallacyclophane 4 prevents their reactions with Ti(O(i)()Pr)(4) to form active catalysts for enantioselective diethylzinc additions to aromatic aldehydes. In contrast, chiral dihydroxy groups in more flexible unclosed metallacyclophane 5 are effective ligands for enantioselective catalytic diethylzinc additions to aromatic aldehydes. |
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