| KF/Al_2O_3催化合成8-氯-4-(2-氯-4-氟苯氧基)喹啉 |
| |
| 引用本文： | 李承周,甘孝贤,邱少君,王光碧. KF/Al_2O_3催化合成8-氯-4-(2-氯-4-氟苯氧基)喹啉[J]. 应用化学, 2000, 0(6) |
| |
| 作者姓名： | 李承周 甘孝贤 邱少君 王光碧 |
| |
| 作者单位： | 西安近代化学研究所应用化学部!西安710065 |
| |
| 摘 要： | 8-氯-4-(2-氯-4-氟苯氧基)喹啉(CCFQ)是DowElanco公司开发的新颖杀菌剂,它具有独特的杀菌机理—抑制与嘧啶生物合成有关的二氢乳清酸酯脱氢酶[1],能防治对现有杀菌剂产生抗性的病原菌,与现有杀菌剂无交互抗性,并且可与多种杀菌剂复配增效.文献[2]合成条件苛刻,原料损失很大,且需色谱分离提纯,收率较低.为解决以上问题,本文以固载氟化钾为催化剂,对4,8-二氯喹啉和2-氯-4-氟苯酚的缩合反应进行研究,发现催化缩合法条件温和,分离方法简单,收率可达75%.ClNCl FOHClKF/Al2O3ClNOClF主要仪器为NICOLET60SXR-FTIR红外光谱仪,KBr压…
|
| 关 键 词： | 氯(氯-氟苯氧基)喹啉 合成 KF/Al_2O_3 |
Synthesis of 8-Chloro-4-(2-chloro-4- fluorophenoxy)quinoline Catalyzed by KF/Al_2O_3 |
| |
| LI Cheng-Zhou.,GAN Xiao-Xian,QIU Shao-Jun,WANG Guang-Bi. Synthesis of 8-Chloro-4-(2-chloro-4- fluorophenoxy)quinoline Catalyzed by KF/Al_2O_3[J]. Chinese Journal of Applied Chemistry, 2000, 0(6) |
| |
| Authors: | LI Cheng-Zhou. GAN Xiao-Xian QIU Shao-Jun WANG Guang-Bi |
| |
| Affiliation: | LI Cheng-Zhou.*,GAN Xiao-Xian,QIU Shao-Jun,WANG Guang-Bi |
| |
| Abstract: | A facile method for the synthesis of title compound(CCFQ) in yield of 75% is reported. It is synthesized by reaction of 4,8-dichloroquin oline with 2-chloro-4-fluorophenol in the presence of KF/Al 2O 3. The product is confirmed by elemental analysis, .1H NMR, IR and MS. |
| |
| Keywords: | chloro(chloro-fluorophenoxy)quinoline synthesis KF/Al_2O_3 |
| 本文献已被 CNKI 等数据库收录！ |
|
