Proline-catalyzed direct inverse electron demand diels-alder reactions of ketones with 1,2,4,5-tetrazines |
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| Authors: | Xie Hexin Zu Liansuo Oueis Hanine R Li Hao Wang Jian Wang Wei |
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| Institution: | Department of Chemistry & Chemical Biology, University of New Mexico, Albuquerque, New Mexico 87131-0001, USA. |
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| Abstract: | An organocatalytic direct inverse electron demand Diels-Alder reaction of ketones with 1,2,4,5-tetrazines has been developed. The process is efficiently catalyzed by proline to give Diels-Alder adducts pyridazines in high yields. |
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