The first synthesis of enantiopure alpha-amino ketimines and amino aziridines |
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| Authors: | Concellón J M Bernad P L Riego E García-Granda S Forcén-Acebal A |
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| Affiliation: | Departamento de Química Física y Analítica, Facultad de Química, Universidad de Oviedo, Julián Clavería 8, 33071 Oviedo, Spain. jmcg@sauron.quimica.uniovi.es |
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| Abstract: | Chiral 1-aminoalkyl chloromethyl ketimines 2 are synthesized in enantiomerically pure form starting from 1-aminoalkyl chloromethyl ketones 1 and different amines. Reduction of amino ketimines 2 and subsequent spontaneous cyclization affords aminoalkyl aziridines 3 with high diastereoisomeric excess and without detectable racemization. |
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