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| STUDIES ON THE TOTAL SYNTHESIS OF MAYTANSINOIDS (Ⅳ)——SYNTHESIS OF MAYTANSINE | |
| 作者姓名： | 顾学钦 潘百川 周启霆 白东鲁 高怡生 |
| 作者单位： | Shanghai Institute of Materia Medica，Academia Sinica，Shanghai Institute of Materia Medica，Academia Sinica，Shanghai Institute of Materia Medica，Academia Sinica，Shanghai Institute of Materia Medica，Academia Sinica，Shanghai Institute of Materia Medica，Academia Sinica |
| 基金项目： | Project supported by the National Natural Science Foundation of China. |
| 摘 要： | This paper reports the total synthesis of optically pure maytansinol and maytansine. The physical constants and spectral data including R_f, m.p., specific rotation, HPLC, UV, CD, IR, NMR, and MS, of synthetic maytansinol and maytansine are identical with those of natural products in all respects. The preliminary biological test showed that synthetic maytansine possesses the same inhibitory activity in vitro against carcinoma cells as the natural product. |
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