| Conjugation of Chitooligosaccharide-5-fluorouracil with Bovine Serum Albumin |
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| 作者姓名： | Rong Min WANG Jing Feng SONG Yu Feng HE Juan Juan MAO Yan LI Key Laboratory of Polymer Materials of Gansu Province Institute of Polymer Northwest Normal University Lanzhou |
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| 作者单位： | Rong Min WANG，Jing Feng SONG，Yu Feng HE，Juan Juan MAO，Yan LI Key Laboratory of Polymer Materials of Gansu Province，Institute of Polymer，Northwest Normal University，Lanzhou 730070 |
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| 基金项目： | 国家自然科学基金;甘肃省自然科学基金 |
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| 摘 要： | The interaction between chitooligosaccharide-5-fluorouracil (COS-5FU) and bovine serum albumin (BSA) was studied by fluorescence spectroscopy. It was found that an energy transfer between COS-5FU and BSA had been occurred. The binding constants were calculated, k298K=1.175×104 L·mol-1.Based on the mechanism of energy transfer of dipole-dipole interaction between the donor and acceptor, the distance between BSA and COS-5FU was determined.
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| 关 键 词： | 血清蛋白 氟尿嘧啶 氟二氧嘧啶 抗癌药 荧光光谱 |
| 收稿时间： | 2006-09-04 |
Conjugation of Chitooligosaccharide-5-fluorouracil with Bovine Serum Albumin |
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| Rong Min WANG,Jing Feng SONG,Yu Feng HE,Juan Juan MAO,Yan LI Key Laboratory of Polymer Materials of Gansu Province,Institute of Polymer,Northwest Normal University,Lanzhou .Conjugation of Chitooligosaccharide-5-fluorouracil with Bovine Serum Albumin[J].Chinese Chemical Letters,2006,17(11):1495-1498. |
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| Authors: | Rong Min WANG Jing Feng SONG Yu Feng HE Juan Juan MAO Yan LI |
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| Abstract: | |
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| Keywords: | Chitooligosaccharide-5-fluorouracil BSA fluorescence spectroscopy |
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