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Thermal studies of isoniazid and mixtures with rifampicin |
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| Authors: | Fátima Duarte Freire Cícero Flávio Soares Aragão Túlio Flávio Accioly de Lima e Moura Fernanda Nervo Raffin |
| Institution: | 1.Laboratório de Desenvolvimento de Medicamentos, Programa de Pós-Gradua??o em Ciências Farmacêuticas, Departamento de Farmácia,Universidade Federal Do Rio Grande Do Norte – UFRN,Natal,Brazil;2.NUPLAM – Núcleo de Pesquisa em Alimentos e Medicamentos,Natal,Brazil;3.Laboratório de Controle de Qualidade de Medicamentos, Programa de Pós-Gradua??o em Ciências Farmacêuticas, Departamento de Farmácia,Universidade Federal do Rio Grande do Norte – UFRN,Natal,Brazil |
| Abstract: | Rifampicin–Isoniazid mixture is a frequently used product in the treatment of tuberculosis. Rifampicin exhibits polymorphism and exists in two polymorphic forms: the stable form I and the metastable form II. The aim of this work was to evaluate the thermal behavior of the binary mixtures of polymorphs I and II of rifampicin and isoniazid by using DSC. Mixtures of different forms (rifampicin form I and II) showed interaction with isoniazid indicating that the mixtures are less stable compared to the drug alone. Interaction was observed in case of both polymorphs of rifampicin. |
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