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| 中国大戟属植物中二萜成分的化学及生物活性 | |
| 引用本文： | 史海明,闵知大,屠鹏飞,李晓波.中国大戟属植物中二萜成分的化学及生物活性[J].化学进展,2008,20(2):375-385. |
| 作者姓名： | 史海明 闵知大 屠鹏飞 李晓波 |
| 作者单位： | 1. 上海交通大学药学院,上海,200240 2. 中国药科大学天然药物化学教研室,南京,210009 3. 北京大学药学院,北京,100083 |
| 摘 要： | 大约有80种大戟属植物广泛分布于我国,并在民间用来治疗皮肤病、水肿、结核或作为泻药和利尿剂使用.本文综述了近20年来中国产大戟属植物中14个骨架类型共150多个二萜类成分的化学研究,包括最近报道的4个具有新骨架的二萜和2个二聚体.中国产大戟属植物中的一些二萜类成分具有抗肿瘤、抗病毒、促进神经生长因子增长、皮肤刺激、致癌以及镇痛安神的活性.本文还就大戟属中二萜类成分可能的生源代谢途径提出了假设,并对该属未来的研究进行了展望. |
| 关 键 词： | 大戟科 大戟属 二萜 生物活性 生源代谢途径 |
| 文章编号： | 1005-281X（2008）02/3-0375-11 |
| 收稿时间： | 2007-04 |
| 修稿时间： | 2007-05 |
Chemistry and Biological Activity of Diterpenoids from Genus Euphorbia in China |
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| Shi Haiming,Min Zhida,Tu Pengfei,Li Xiaobo.Chemistry and Biological Activity of Diterpenoids from Genus Euphorbia in China[J].Progress in Chemistry,2008,20(2):375-385. | |
| Authors: | Shi Haiming Min Zhida Tu Pengfei Li Xiaobo |
| Abstract: | About 80 species of genus Euphorbia distribute widely in China, which are used in folk medicine to cure skin diseases, edema, tuberculosis, and as a purgative and diuretic medicine. The progress on chemistry of more than 150 diterpenoids owning fourteen skeleton types from Chinese Euphorbia species in the past 20 years is reviewed, including four diterpenoids with novel skeleton and two dimers reported recently. Some diterpenoids isolated from Chinese Euphorbia species show antitumor, antivirus, NGF-promoting, skin-irritating, tumor-promoting, analgesic and sedative activities. The possible biogenetic ways of diterpenoids from genus Euphorbia are also presented. Meanwhile, the research of this genus in future is prospected. |
| Keywords: | euphorbiaceae Euphorbia diterpenoids biological activities biogenetic ways |
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