Chemical transformations of 6-[(1-methyl-4-nitro-5-imidazolyl)-thio]purine (azathioprine) |
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| Authors: | P M Kochergin E V Aleksandrova V S Korsunskii |
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| Institution: | (1) Center of the Chemistry of Medicinals, All-Russia Scientific-Research Chemical Pharmaceutical Institute, Moscow;(2) Zaporozhe State Medical University, Zaporozhe, Ukraine |
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| Abstract: | The chemical transformations of 6-(1-methyl-4-nitro-5-imidazolyl)thio]purine (azathiopurine) —hydrogenation, acetylation, alkylation by lower alkyl halides at positions 7 and 9 of the purine ring, hydrolytic cleavage at the C(6)–S and S–C(5) bonds— were studied.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 372–379, March, 2000. |
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| Keywords: | azathioprine nitroimidazolylthiopurines alkylation acetylation hydrogenation hydrolysis |
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