| Study on the Ring Eulargment Reaction: Synthesis of 7,8,13, 13a-tetrahydroisoindolo[1,2-b][3]benzazepine and 5,6,8,9,14,14a-hexahydroisoquino[1,2-b][3]benzazepine |
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| 作者姓名： | Yu Xin LIU Xiao Tian LIANG* Institute of Materia Medica Chinese Academy of Medical Sciences &Peking Union Medical College Xian NongTan Street Beijing |
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| 作者单位： | Yu Xin LIU，Xiao Tian LIANG* Institute of Materia Medica，Chinese Academy of Medical Sciences &Peking Union Medical College 1 Xian NongTan Street，Beijing 100050 |
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| 摘 要： | In our research on the ring enlargement of certain N-heterocycles, a general procedure for the ring enlargement with the insertion of an extra -CH2- was improved and shown in Scheme I1.Scheme IThe procedure had been carried out with such N-heterocycles as 2-methyl-1,2,3,4-tetrahydroisoquinoline2, tetrahydroberberine and strychnine3 with expected results. Thus, the procedure shown in Scheme I provides a new approach to the synthesis of larger N-heterocycles.Isoindolo1,2-b]3]benzazepines a…
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Study on the Ring Eulargment Reaction: Synthesis of 7,8,13, 13a- tetrahydroisoindolo[1,2-b][3]benzazepine and 5,6,8,9,14,14a-hexahydroisoquino[1,2-b][3]benzazepine |
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| Yu Xin LIU,Xiao Tian LIANG* Institute of Materia Medica,Chinese Academy of Medical Sciences &Peking Union Medical College Xian NongTan Street,Beijing .Study on the Ring Eulargment Reaction: Synthesis of 7,8,13, 13a-tetrahydroisoindolo[1,2-b][3]benzazepine and 5,6,8,9,14,14a-hexahydroisoquino[1,2-b][3]benzazepine[J].Chinese Chemical Letters,2001(1). |
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| Authors: | Yu Xin LIU Xiao Tian LIANG Institute of Materia Medica Chinese Academy of Medical Sciences &Peking Union Medical College Xian NongTan Street Beijing |
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| Institution: | Yu Xin LIU,Xiao Tian LIANG* Institute of Materia Medica,Chinese Academy of Medical Sciences &Peking Union Medical College 1 Xian NongTan Street,Beijing 100050 |
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| Abstract: | A new approach to the synthesis of 7,8,13,13a-tetrahydroisoindolo1,2-b] 3]benzazepine 5 and 5,6,8,9,14,14a-hexahydroisoquino1,2-b]3]benzazepine 9 and related compounds is described as using ring expansion of N-heterocycles. |
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| Keywords: | Ring enlargement isoindolo[1 2-b][3]benzazepines isoquino[1 2-b][3]benzazepines synthesis |
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