First artificial receptors and chemosensors toward phosphorylated peptide in aqueous solution |
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Authors: | Ojida Akio Mito-Oka Yasuko Inoue Masa-Aki Hamachi Itaru |
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Institution: | Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Fukuoka, 812-8581, Japan. |
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Abstract: | The first fluorescent chemosensors toward a native phosphorylated peptide are successfully synthesized. Dinuclear zinc(II)-dipicolylamine-based anthracene (1, 2) can selectively recognize and sense phosphorylated species with an increase in the fluorescence intensity. We also demonstrated that these artificial receptors fluorometrically detect a phosphorylated peptide with high affinity (>107 M-1) in aqueous solution. |
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