Improved synthesis of substituted pyrido[2,3-d]pyrimidinediones |
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Authors: | Gwydion H. Churchill Steven A. RawLyn Powell |
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Affiliation: | Pharmaceutical Development, AstraZeneca, Charter Way, Macclesfield SK10 2NA, UK |
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Abstract: | An improved methodology for the synthesis of substituted pyrido[2,3-d]pyrimidinediones from 6-aminouracils and the corresponding enaminone has been developed which provides high yields via an operationally simple process. The method has been extended to encompass a range of electron-rich enaminones, a substrate class that does not perform well under the standard conditions. |
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Keywords: | Heteroannulation Enaminone 6-Aminouracil Pyrimidinedione |
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