Deconvolution method for accurate determination of overlapping peak areas in chromatograms. |
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| Authors: | T J Nelson |
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| Institution: | Neural Systems Section, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20892. |
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| Abstract: | A method is described for deconvoluting chromatograms which contain overlapping peaks. Parameters can be selected to ensure that attenuation of peak areas is uniform over any desired range of peak widths. A simple extension of the method greatly reduces the negative overshoot frequently encountered with deconvolutions. The deconvoluted chromatograms are suitable for integration by conventional methods. |
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