Spectroscopic,thermal and antimicrobial properties of the copper(II) complex of Schiff base derived from 2‐(salicylidene) aminopyridine |
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| Authors: | Gladiola Tantaru Maria‐Cristina Popescu Veronica Bild Antonia Poiata Gabriela Lisa Cornelia Vasile |
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| Institution: | 1. 'Gr. T. Popa' University of Medicine and Pharmacy, Faculty of Pharmacy, , Iasi, Romania;2. ‘Petru Poni’ Institute of Macromolecular Chemistry, , Iasi, Romania;3. 'Gr. T. Popa' University of Medicine and Pharmacy, Faculty of Medicine, , Iasi, Romania;4. 'Gh. Asachi' Technical University, Department of Chemical Engineering, , Iasi, Romania |
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| Abstract: | Schiff bases and their complex combinations with metallic ions represent a class of compounds with antimicrobial activity. A ligand was prepared by condensation of the salicylaldehyde with 2‐aminopyridine obtaining 2‐(salicylidene) aminopyridine (SB) with a high capacity for complexing Cu(II) ions. The new compound has been characterized by physical constants (melting point, solubility, stability) and the chemical structure was confirmed by elemental, spectral (IR, UV–visible, 1H NMR and 13C‐NMR) and thermal analyses. The elemental analysis gives a coordination ratio of 1:2 metal:Schiff base. Lethal dose 50 (DL50) values of new Schiff base and their complex with metallic ions were established. The antimicrobial activity of this complex was tested in comparison with the activity of the corresponding Schiff base on strains of Staphylococcus aureus, Bacillus cereus, Bacillus subtilis, Escherichia coli, Candida albicans, and Klebsiella. These were compared with the activity of the reference drugs (chloramphenicol, tetracycline, ofloxacin and nystatin) on the above‐mentioned strains. It has been established that all compounds tested were very active against both Gram‐positive and Gram‐negative bacteria. Copyright © 2012 John Wiley & Sons, Ltd. |
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| Keywords: | Schiff base 2‐(salicylidene) aminopyridine Cu(II) complex antimicrobial activity toxicity |
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