Synthesis,characterization and bioactivity determination of ferrocenyl urea derivatives |
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| Authors: | Wei Liu Yanting Tang Yu Guo Bo Sun Hemin Zhu Yanyan Xiao Dandan Dong Cheng Yang |
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| Affiliation: | 1. High Throughput Molecular Drug Discovery Center, Tianjin International Joint Academy of Biotechnology and Medicine, TEDA, , Tianjin, 300457 People's Republic of China;2. College of Sciences, Tianjin University of Science and Technology, , Tianjin, 300457 People's Republic of China |
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| Abstract: | Fourteen new ferrocene derivatives containing urea linker were synthesized from the reaction of ferrocenecarbonyl azide with aromatic amines. The structures of the synthetic compounds were confirmed by 1H NMR, 13C NMR, IR, mass spectrometry and elemental analysis. These organometallic compounds were evaluated by in vitro protease assay using fluorogenic substrate peptide, and several showed potent inhibition against HIV‐1 protease. Copyright © 2012 John Wiley & Sons, Ltd. |
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| Keywords: | ferrocene urea biological activity HIV‐1 protease inhibitors |
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