Efficient Synthesis of 3‐Methyl‐Flavanones and Evaluation of Their Anti‐Bacterial Activity |
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| Authors: | Beena Nawghare Sharad Funde Abdul Raheem Pradeep Lokhande |
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| Institution: | The Centre for Advanced Studies, Department of Chemistry, University of Pune, Pune 411 007, India |
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| Abstract: | A series of 2‐phenyl‐2,3‐dihydrochromon‐4‐one derivatives (flavanone derivatives) were synthesized by silica gel assisted isomerization of several α‐methyl‐2′‐hydroxy chalcones in 74%–88% yield. These flavanones were further oxidized to 3‐methyl flavones by using iodine in dimethyl sulphoxide at 60°C in presence of acid. The newly synthesized derivatives were evaluated for in vitro study against Staphylococcus aureus, Micrococcus luteus and Staphylococcus epidermis. |
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| Keywords: | cyclization oxidation chalcones silica gel 3‐methyl‐flavanones |
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