Palladium‐catalyzed cyclization of β‐bromo‐α,β‐unsaturated ketones with arylhydrazines leading to 3‐substituted 1‐aryl‐1 H‐pyrazoles |
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| Authors: | Hye Kyung Lee Chan Sik Cho |
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| Institution: | Department of Applied Chemistry, Kyungpook National University, , Daegu, 702‐701 South Korea |
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| Abstract: | β‐Bromo‐α,β‐unsaturated ketones are condensed with arylhydrazines to form hydrazones, which are in situ intramolecularly cyclized into 3‐substituted 1‐aryl‐1 H‐pyrazoles under a catalytic system of Pd(OAc)2/1,3‐bis(diphenylhosphino)propane (dppp)/NaOtBu. Copyright © 2012 John Wiley & Sons, Ltd. |
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| Keywords: | arylhydrazines 1‐aryl‐1 H‐pyrazoles β ‐bromo‐α β ‐unsaturated ketones C– N bond formation palladium catalyst |
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