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Interactions with herring sperm DNA and biological studies of sparfloxacin drug‐based copper(II) compounds
Authors:Mohan N. Patel  Hardik N. Joshi  Chintan R. Patel
Affiliation:Department of Chemistry, Sardar Patel University, , Vallabh Vidyanagar, 388120 Gujarat, India
Abstract:Copper(II) complexes of the type [Cu(SPF)(Ln)Cl] (where SPF is sparfloxacin and Ln = substituted terpyridines) were synthesized and found to have a distorted octahedral geometry. Superoxide dismutase‐like activity of the complexes was measured using a nitroblue tetrazolium/reduced nicotinamide adenine dinucleotide/phenazine methosulfate system and expressed in terms of the concentration of complex which terminates the formation of formazan by 50% (IC50 value), which was found to range from 0.572 to 1.522 µm . Interactions of the complexes with herring sperm DNA were studied by absorption titration, viscosity measurement and gel electrophoresis under physiological conditions. The antimicrobial efficiency of the complexes was tested against five different microorganisms and showed good biological activity. All the complexes showed good cytotoxic activity, with LC50 values ranging from 4.01 to 9.64 µg ml?1. Copyright © 2012 John Wiley & Sons, Ltd.
Keywords:sparfloxacin  intercalation  IC50  LC50  bactericidal activity
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