Mixed metal MgO–ZrO2 nanoparticle‐catalyzed O‐tert‐Boc protection of alcohols and phenols under solvent‐free conditions |
| |
| Authors: | Manoj B Gawande Sharad N Shelke Paula S Branco Anuj Rathi Rajesh K Pandey |
| |
| Institution: | 1. REQUIMTE, Departamento de Química, Faculdade de Ciênciase Tecnologia, FCT, Universidade Nova de Lisboa, , Portugal;2. Department of Chemistry, SSGM College, , Kopargaon, MH‐423601 India;3. Jubilant Chemsys Ltd., B‐34, Sector‐58, , New Delhi, Noida‐201301 India;4. Department of Chemistry, Marquette University, , Milwaukee, WI‐53233, USA |
| |
| Abstract: | An environmentally benign method for O‐tert‐Boc protection of alcohols and phenols catalyzed by MgO–ZrO2 nanoparticles under solvent‐free conditions is described. A variety of phenols, alcohols (aliphatic and aromatic) were converted to corresponding O‐tert‐Boc products in good to excellent yield (50–95%). The present protocol is expedient, simple, and efficient under solvent‐free conditions. The MgO–ZrO2 Nps are easily prepared from inexpensive precursors, and are reusable, recyclable and chemoselective. Copyright © 2012 John Wiley & Sons, Ltd. |
| |
| Keywords: | O‐tert‐butoxycarbonylation phenol and alcohol mixed metal oxides nanoparticles solvent‐free reusable and recyclable |
|
|
