2-bromo-3,3,3-trifluoropropene: A facile trifluoromethylacetylene anion synthon |
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| Authors: | Alan R. Katritzky Ming Qi Adam P. Wells |
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| Affiliation: | Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200 USA |
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| Abstract: | The introduction of trifluoromethylacetylene units into organic compounds has been further studied and extended. The direct reaction of two equivalents of Lithium Diisopropylamide with 2-bromo-3,3.3-trifluoropropene gave lithium trifluoromethylacetylide, the anion of which was trapped in greater than 90% overall yield with a variety of electrophiles. |
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| Keywords: | Trifluoromethylacetylene 2-Bromo-3,3,3-trifluoropropene Organic compounds |
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