Catalytic enantioselective Diels-Alder reaction by self-assembly of the components on a Lewis acid template |
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| Authors: | Ward Dale E Souweha Michael Santos |
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| Institution: | Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon, SK, S7N 5C9 Canada. Dale.Ward@usask.ca |
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| Abstract: | Thermal Diels-Alder reaction of 2,4-hexadienol with methyl acrylate is unselective. By simultaneous coordination of diene and dienophile to a chiral bimetallic Lewis acid catalyst, a LACASA-DA reaction occurs with complete control of regio-, diastereo-, and enantioselectivity to give a single adduct. reaction: see text] |
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