Enantioselective addition of terminal alkynes to aldehydes catalyzed by a Cu(I)-TRAP complex |
| |
Authors: | Asano Yohsuke Hara Kenji Ito Hajime Sawamura Masaya |
| |
Institution: | Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan. |
| |
Abstract: | The addition of terminal alkynes to aromatic aldehydes was carried out under mild conditions in the presence of a Cu-phosphine complex, which was prepared in situ from Cu(O-t-Bu) and TRAP chiral bisphosphine, to yield enantiomerically enriched propargyl alcohols with moderate enantioselectivities. Furthermore, according to stoichiometric reactions, the reaction presumably involves the addition of a TRAP-coordinated Cu(I) acetylide to an aldehyde. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|