| Divergent defluorocarboxylation of α-CF3 alkenes with formate via photocatalyzed selective mono-or triple C–F bond cleavage |
| |
| 作者姓名： | Xing-Yu Wang Pei Xu Wen-Wen Liu Hao-Qiang Jiang Song-Lei Zhu Dong Guo Xu Zhu |
| |
| 作者单位： | Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical University |
| |
| 基金项目： | supported by the National Natural Science Foundation of China (22001224)；;the Natural Science Foundation of Jiangsu Province (BK20201014, BK20200106)； |
| |
| 摘 要： | Unprecedented divergent synthesis of gem-difluorovinylacetic acid and glutaric acid derivatives from α-CF3 alkenes with formate as the carbonyl source was disclosed.The reaction can undergo selective mono-or triple C-F bond cleavage by simply switching the photocatalyst and hydrogen atom transfer(HAT) catalyst under visible-light-induced conditions at room temperature.Foramte acts as both the C1 source and the reductant through the generation of CO2·- species,whi...
|
|
