| Rh(Ⅱ)-catalyzed intermolecular carboamination of pyridines via double Csp2–H bond activations |
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| 作者姓名： | Zhongfeng Luo Jingxing Jiang Lifang Zou Xiaoyu Zhou Junshan Liu Zhuofeng Ke Fengjuan Chen Huanfeng Jiang Wei Zeng |
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| 作者单位： | 1. Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology |
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| 基金项目： | supported by the National Natural Science Foundation of China (22271100, 21973113)；;the Key-Area Research and Development Program of Guangdong Province (2020-B010188001)；;the Guangdong Basic and Applied Basic Research Foundation (2023A1515010070)；;the China Postdoctoral Science Foundation (2021M701243)； |
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| 摘 要： | We disclose the development of the Rh-catalyzed amine-directed remote 5,6-carboamination protocol of pyridines via dual Csp2–H functionalizations. A variety of readily available 2-aminopyridines and 1,2,3-triazoles are allowed for coupling cyclization to access polyfunctionalized azaindoles. Mechanistic studies including DFT calculations unveil that relay carbenoidelectrophilic addition to pyridines and the sequential pyridyl Csp2–H amination are involved in this transforma...
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