An example of quality control of fine chemical intermediates: related impurity analysis of industrial phthalic anhydride by reversed-phase high-performance liquid chromatography |
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| Authors: | Lin-feng Zhou Jun-qin Qiao Hong-zhen Lian Xin Ge |
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| Affiliation: | 1. Key Laboratory of Analytical Chemistry for Life Science (Ministry of Education of China), School of Chemistry and Chemical Engineering and Center of Materials Analysis, Nanjing University, 22 Hankou Road, Nanjing, 210093, China
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| Abstract: | A reliable reversed-phase high-performance liquid chromatographic method has been developed for analysis of related impurities in industrial phthalic anhydride (PA). Maleic acid (hydrolysis product of maleic anhydride), phthalimide, and benzoic acid were separated from phthalic acid (Pa, hydrolysis product of PA) on a C18 column by gradient elution with acetonitrile and 0.1% (v/v) aqueous perchloric acid solution. This method is simple, sensitive, and accurate, and has been successfully applied to quality control of PA for industrial use. |
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