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Sphenadilactones A and B, two novel nortriterpenoids from Schisandra sphenanthera
Authors:Xiao Wei-Lie  Pu Jian-Xin  Chang Ying  Li Xiao-Li  Huang Sheng-Xiong  Yang Liu-Meng  Li Li-Mei  Lu Yang  Zheng Yong-Tang  Li Rong-Tao  Zheng Qi-Tai  Sun Han-Dong
Affiliation:State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, P. R. China.
Abstract:[structure: see text] Two novel nortriterpenoid compounds, sphenadilactones A (1) and B (2), have been isolated from the leaves and stems of Schisandrasphenanthera. The structural elucidation of 1 and 2 was accomplished by extensive NMR analysis. The relative stereochemistry of 1 was established by single-crystal X-ray crystallography. Both compounds were tested for their cytotoxicities against K562, A549, and HT-29, and compound 1 was further tested for its anti-HIV-1 activity.
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