Sphenadilactones A and B, two novel nortriterpenoids from Schisandra sphenanthera |
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Authors: | Xiao Wei-Lie Pu Jian-Xin Chang Ying Li Xiao-Li Huang Sheng-Xiong Yang Liu-Meng Li Li-Mei Lu Yang Zheng Yong-Tang Li Rong-Tao Zheng Qi-Tai Sun Han-Dong |
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Affiliation: | State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, P. R. China. |
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Abstract: | [structure: see text] Two novel nortriterpenoid compounds, sphenadilactones A (1) and B (2), have been isolated from the leaves and stems of Schisandrasphenanthera. The structural elucidation of 1 and 2 was accomplished by extensive NMR analysis. The relative stereochemistry of 1 was established by single-crystal X-ray crystallography. Both compounds were tested for their cytotoxicities against K562, A549, and HT-29, and compound 1 was further tested for its anti-HIV-1 activity. |
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