| 傅里叶变换红外光谱鉴别正常和良恶性乳腺组织 |
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| 引用本文： | 赵瑾,刘亚奇,徐怡庄,张元福,吴瑾光,侯宽永,赵红梅,雷玉涛,周孝思,徐智,凌晓锋. 傅里叶变换红外光谱鉴别正常和良恶性乳腺组织[J]. 高等学校化学学报, 2011, 32(2): 246-251 |
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| 作者姓名： | 赵瑾 刘亚奇 徐怡庄 张元福 吴瑾光 侯宽永 赵红梅 雷玉涛 周孝思 徐智 凌晓锋 |
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| 作者单位： | 1. 北京大学第三医院普通外科, 北京 100191; 2. 北京大学化学与分子工程学院, 北京 100871 |
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| 基金项目： | 北京市自然科学基金项目(批准号:2072020)资助 |
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| 摘 要： | 应用傅立叶变换红外光谱及衰减全反射法, 检测乳腺手术中切除的四种新鲜离体乳腺组织77例，包括正常乳腺组织18例，乳腺增生13例，乳腺纤维腺瘤21例，乳腺癌25例. 用方差分析和秩和检验的方法比较上述四类乳腺组织红外光谱各谱带的峰位、相对峰强及半高宽结果表明：与蛋白、脂质、糖类与核酸相关的谱带在上述四种不同类型乳腺组织之间均存在高度的统计学差异（P<0.05）. 因此，应用FTIR（Fourier Transform Infrared Spectroscopy）可以区分正常乳腺组织、乳腺增生、乳腺纤维腺瘤以及乳腺癌四种乳腺组织，这将为今后在手术中运用原位在体FTIR指导外科医生进行精准手术奠定基础.
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| 关 键 词： | FTIR光谱 乳腺癌 乳腺纤维腺瘤 乳腺增生 |
| 收稿时间： | 2010-09-25 |
FTIR Spectrum Comparisons Among the Breast tissues:the Normal Tissues,Hyperplasia,Fibroadenoma and Cancer |
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| ZHAO Jin,LIU Ya-Qi,XU Yi-Zhuang,ZHANG Yuan-Fu,WU Jin-Guang,HOU Kuan-Yong,ZHAO Hong-Mei,LEI Yu-Tao,ZHOU Xiao-Si,XU Zhi,LING Xiao-Feng. FTIR Spectrum Comparisons Among the Breast tissues:the Normal Tissues,Hyperplasia,Fibroadenoma and Cancer[J]. Chemical Research In Chinese Universities, 2011, 32(2): 246-251 |
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| Authors: | ZHAO Jin LIU Ya-Qi XU Yi-Zhuang ZHANG Yuan-Fu WU Jin-Guang HOU Kuan-Yong ZHAO Hong-Mei LEI Yu-Tao ZHOU Xiao-Si XU Zhi LING Xiao-Feng |
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| Affiliation: | 1. Department of General Surgery, Peking University Third Hospital, Beijing 100191, China; 2. College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China |
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| Abstract: | Fourier transform infrared(FTIR) spectra of 77 freshly removed breast tissues were collected by a spectrometer equipped with an Attenuated total reflectance(ATR) probe.These breast samples included 18 normal tissues,13 hyperplasia,21 fibroadenoma and 25 cancer.For each FTIR spectrum,the peak positions(P),relative intensity ratios(I) and full width at half maximum(F) of the 13 bands were measured.The differences among the four types of breast tissue were compared by ANOVA(Analysis of Variance) and rank-sum t... |
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| Keywords: | Fourier transform infrared(FTIR) spectroscopy Breast cancer Fibroadenoma Hyperplasia of mammary glands Attenuated total reflectance(ATR) |
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