| 黄芩类药物与人血清白蛋白相互作用的研究 |
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| 引用本文： | 王宁,刘忠英,胡秀丽,卜凤泉,赵学忠.黄芩类药物与人血清白蛋白相互作用的研究[J].高等学校化学学报,2011,32(2):241-245. |
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| 作者姓名： | 王宁 刘忠英 胡秀丽 卜凤泉 赵学忠 |
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| 作者单位： | 1. 吉林大学药学院, 长春 130021;
2. 吉林省人民医院肾脏内科, 长春 130021;
3. 吉林大学白求恩第一医院心血管内科, 长春 130021 |
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| 摘 要： | 本文利用荧光猝灭技术和紫外可见分光光度法研究了黄芩苷和汉黄芩苷与人血清白蛋白的结合性质，由药物对血清白蛋白的荧光猝灭作用求出了其结合常数. 根据热力学参数，确定了结合力的性质. 并进一步研究了Zn2+, Mg2+, Al2+,和 Cu2+存在时对结合性质的影响. 不仅对于揭示体内药物动力学问题，指导临床合理用药具有一定意义，而且对于进行药物分子设计、开发新药等也具有重要指导意义.
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| 关 键 词： | 黄芩苷 汉黄芩苷 人血清白蛋白 荧光猝灭 |
| 收稿时间： | 2010-10-04 |
Interaction Between Scutellaria baicalensis Georgi and Human Serum Albumin |
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| WANG Ning,LIU Zhong-Ying,HU Xiu-Li,BU Feng-Quan,ZHAO Xue-Zhong.Interaction Between Scutellaria baicalensis Georgi and Human Serum Albumin[J].Chemical Research In Chinese Universities,2011,32(2):241-245. |
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| Authors: | WANG Ning LIU Zhong-Ying HU Xiu-Li BU Feng-Quan ZHAO Xue-Zhong |
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| Institution: | 1. College of Pharmacy, Jilin University, Changchun 130021, China;
2. Department of Nephrology, Jilin Province People’s Hospital, Changchun 130021, China;
3. Department of Cardiovascular Medicine, First Hospital of Jilin University, Changchun 130021, China |
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| Abstract: | The interactions of baicalin and wogonoside with human serum albumin(HSA) were studied by fluorescence quenching and ultraviolet-visible absorption spectrometry.The binding constants were obtained by fluorescence quenching of drug with serum albumin.The main acting binding forces of baicalin and wogonoside to serum albumins were hydrophobic force according to the thermodynamic parameters.The effects of me-{tal} ions,such as Zn2+,Mg2+,Al3+ and Cu2+on binding constants were also evaluated.It is not only valua... |
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| Keywords: | Baicalin Wogonoside Human serum albumin Fluorescence quenching |
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