Electrochemical oxidation of catechol in the presence of 2-thiouracil: application to electro-organic synthesis |
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| Institution: | 1. Division of Biomedical Research, Department of Theoretical and Applied Sciences, and Center of Neuroscience, University of Insubria, I-21052 Busto Arsizio, Italy;2. Department of Biochemistry, Research and Innovation Centre, University of Regina, Regina, SK, Canada;3. Science for Life Laboratory, KTH⿿Royal Institute of Technology, Stockholm, Sweden;4. Santa Lucia IRCCS Foundation, I-00143 Rome, Italy;5. Department of Experimental Medicine and Surgery, University of Rome ⿿Tor Vergata⿿, I-00133 Rome, Italy |
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| Abstract: | The electrochemical oxidation of catechol in the presence of 2-thiouracil (as a nucleophile) has been studied in aqueous solutions using cyclic voltammetry and controlled-potential coulometric techniques. The results indicate that catechol participating in a 1,4 (Michael) addition reaction converts to a new thiadiazafluorenone compound. The electrochemical synthesis of this compound has been successfully performed in an undivided cell in a good yield and purity and was characterized by IR, 1H and 13C NMR, mass spectrometry and elemental analysis. |
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