Simultaneous determination of ascorbic acid,dopamine and serotonin at poly(phenosafranine) modified electrode |
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| Institution: | 1. School of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412007, China;2. Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Hunan Provincial Universities, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang 421008, China;3. School of Life Sciences and Bioengineering, Nelson Mandela African Institution of Science and Technology, P.O. Box 447, Arusha, Tanzania;1. Department of Chemistry and Research Institute for Convergence of Basic Science, Hanyang University, Seoul 04763, Republic of Korea;2. Department of HY-KIST Bio-convergence, Hanyang University, Seoul 04763, Republic of Korea |
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| Abstract: | The oxidation of phenosafranine at glassy carbon electrode gives rise to stable redox active electropolymerized film containing a polyazine moiety (poly(phenosafranine)). The redox response of the poly(phenosafranine) film was observed at the modified electrode at different pH and the pH dependence of the peak potential is 60 mV/pH, which is very close to the expected Nernstian behavior. The apparent diffusion coefficient (Dapp) of poly(phenosafranine) film was measured as 2.51 × 10?9 cm2/s. This film exhibits potent and persistent electron-mediating behavior followed by well-separated oxidation peaks towards ascorbic acid (AA), dopamine (DA) and serotonin with activation overpotential, which is 200 mV lower than that of the bare electrode for AA oxidation. Using differential pulse voltammetry (DPV) studies, the limit of detection of DA in the presence of AA is estimated to be in the submicromolar regime. This method has been used for determining DA and AA concentrations in real samples with satisfactory results. |
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