Facile and efficient synthesis of 2-substituted-Nl-carbethoxy-2,3-dihydro-4(1H)-quinazolinones in fluorous solvent

A facile,efficient and novel approach to access 2-substituted-N_1-carbethoxy-2,3-dihydro-4(1H)-quinazolinones was developed by condensation of substituted N-carbethoxyanthranilamide with alkyl,aromatic or heteroaromatic aldehydes in the refluxing 2,2,2- trifluoroethanol or hexafluoroisopropanol using p-toluenesulfonic acid as catalyst.