Preparation and evaluation of unimolecular pentavalent and hexavalent antigenic constructs targeting prostate and breast cancer: a synthetic route to anticancer vaccine candidates |
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| Authors: | Ragupathi Govind Koide Fusataka Livingston Philip O Cho Young Shin Endo Atsushi Wan Qian Spassova Maria K Keding Stacy J Allen Jennifer Ouerfelli Ouathek Wilson Rebecca M Danishefsky Samuel J |
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| Affiliation: | Laboratory of Tumor Vaccinology, Clinical Immunology Service, Department of Medicine, the Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, New York, New York 10021, USA. |
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| Abstract: | Several novel, fully synthetic, carbohydrate-based antitumor vaccines have been assembled. Each construct consists of multiple cancer-related antigens displayed on a single polypeptide backbone. Recent advances in synthetic methodology have allowed for the incorporation of a complex oligosaccharide terminating in a sialic acid residue (i.e., GM2) as one of the carbohydrate antigens. Details of the vaccine synthesis as well as the results of preliminary immunological investigations are described herein. |
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