A unique highly oxygenated pyrano[4,3-c][2]benzopyran-1,6-dione derivative with antioxidant and cytotoxic activities from the fungus Phellinus igniarius |
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Authors: | Wang Ying Mo Shun-Yan Wang Su-Juan Li Shuai Yang Yong-Chun Shi Jian-Gong |
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Institution: | Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. |
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Abstract: | structure: see text] A unique pyrano4,3-c]2]benzopyran-1,6-dione derivative with an unprecedented carbon skeleton, phelligridin G (1), has been isolated from the fruiting body of the fungus Phellinus igniarius. Its structure was elucidated by detailed spectroscopic analysis. A possible biogenetic origin of 1 mediated by the fungal metabolite precursor 4-hydroxy-6-methyl-2-pyrone was postulated. Phelligridin G (1) showed antioxidant activity inhibiting rat liver microsomal lipid peroxidation and moderate selective cytotoxic activities against human cancer cell lines. |
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